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Recent TMS and HBOT Studies June 2019 Update

The pace of studies being published on the effects of TMS continues to climb, recently reported to be more than 25 per week.

Two new and notable studies have confirmed the positive effect of TMS on cognitive performance and its potential implications for persons suffering from dementia/Alzheimer’s Disease. Also listed below, notable remarks on TMS therapy as a prophylactic treatment for migraine, and a study exploring Hyperbaric Oxygen Therapy (HBOT) in men’s health.

TMS and Cognitive Performance

Duke University news: May 15, 2019
Published in the Journal PloS One. Researchers in Duke University’s Department of Neurology found that both healthy older (18 participants) as well as healthy younger adults (29 participants) who received TMS therapy performed working memory tasks better than those study participants who received a placebo. The study utilized functional Magnet Resonance Imaging (fMRI) to determine stimulation targets for LDLPFC 5Hz stimulation.

Online repetitive transcranial magnetic stimulation during working memory in younger and older adults: A randomized within-subject comparison L. Beynel , S. W. Davis , C. A. Crowell, S. A. Hilbig, W. Lim, D. Nguyen, H. Palmer, A. Brito, A. V. Peterchev , B. Luber, S. H. Lisanby, R. Cabeza , L. G. Appelbaum; Published: March 22, 2019


Performed at Northwestern University, published in the Journal Neurology: fMRI-guided TMS therapy was used to stimulate the patients’ hippocampus through targeting of the parietal lobe, a brain structure with known synchronicity with the hippocampus. Sixteen (16) adults aged between 64 and 80 who exhibited normal age-related memory deficits were treated with TMS for 20 minutes per day for five (5) consecutive days. After 24 hours had elapsed following the patients’ last treatment, the study participants were retested and performed at the same cognitive level as the younger control group. Notably, a second group of older adults who received a placebo instead of TMS therapy did not show an improvement in memory function.

Network-targeted stimulation engages neurobehavioral hallmarks of age-related memory decline Aneesha S. Nilakantan, M.-Marsel Mesulam, Sandra Weintraub, Erica L. Karp, Stephen VanHaerents, Joel L. VossNeurology May 2019, 92 (20) e2349-e2354; DOI:10.1212/WNL.0000000000007502

TMS as Prophylactic Option for Migraine Sufferers

TMS has been FDA-approved since 2013 to treat major depression and migraines. In an additional TMS-related development, Doctor Michael Cutrer, a neurologist at the Mayo Clinic, told the audience at the April 2019 American College of Physicians Internal Medicine Meeting in Philadelphia, that TMS therapy was effective in stopping the aura in Migraines and a reasonable alternative prophylactic option for migraine sufferers who feared repeated attacks.

HBOT in Men’s Health

Hyperbaric Oxygen Therapy (HBOT) has also received a spate of new positive clinical research outcomes.

Most notably: On April 30, 2019 an article appeared in PubMed from the Med Gas Res. 2018 April 18:8(1) 29-33 entitled: “Clinical utility of hyperbaric oxygen therapy in genitourinary medicine” by Gandhi, J. et al. The authors noted that HBOT was making gradual strides in genitourinary medicine “due to its low risk and likeliness to achieve favorable results”. The authors also pointed success with HBOT in treating radiation cystitis, erectile dysfunction secondary to urethroplasty, blood testosterone and other indications.

Between 2016 and today there have been a number of clinical studies that have concluded that HBOT has a positive impact on Erectile Dysfunction although there have been some studies that found the improvement in ED without being able to determine an increase in serum testosterone levels in study participants.

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