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Characterized by chronic and widespread pain, tenderness and soreness, fibromyalgia usually includes pervasive and overwhelming fatigue and can have an impact on sleep, memory and mood. It is very common, affects millions of people every year and occurs more frequently in women than men. The intensity of fibromyalgia can vary depending on time of day, with the late afternoon and evening often being the worst. It can also vary depending on fatigue, weather and time of year. Researchers believe that in people who suffer from fibromyalgia the brain amplifies pain senses. While there is no known cure, there are groundbreaking therapies and treatments that can help reduce the intensity of the pain by focusing on the neurological origin.